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New Weight Loss Pill Shows Positive Early Results, Says Study

Whitney | August 2nd, 2012

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Researchers are currently examining a new weight loss pill that could help people shed pounds more effectively. The medication, known in the preliminary stages as JD5037, works by suppressing appetite so dieters consume fewer calories. The drug is currently in the very early stages of development and has yet to be tested on human subjects. However, early clinical studies on mice suggest this drug may be a useful tool for people looking to achieve long-term weight loss.

About the new weight loss pill

JD5037 works by increasing sensitivity to the body’s own hormone leptin, which serves as a natural appetite suppressant. Researchers found that obese individuals become desensitized to leptin, which allows them to consume larger portions of food. Adding leptin to the body through supplementation does not solve the problem, since it does not make the body more sensitive to the effects of the hormone.

Instead, sensitizing the body to leptin that is already produced by the body, which is how this new weight loss pill works, appears to increase feelings of satiety.

The research on JD5037 has been performed by George Kunos from the National Institute on Alcohol Abuse and Alcoholism. Kunos found that sensitization is achieved through the blocking of cannabinoid receptors that lead to feelings of hunger. A former weight loss pill also worked by blocking these receptors, but resulted in serious psychiatric side effects. Researchers believe that because JD5037 does not enter the brain in the same manner, psychiatric side effects will be avoided.

Currently, JD5037 has only been tested on mice, but positive results have prompted researchers to pursue clinical studies on humans next.

How to lose weight effectively

While this new weight loss pill has showed some promise in the early research phase, successful weight loss stories involve much more than simply popping a pill.

Dr. Michael Kaplan, founder and chief medical officer of The Center for Medical Weight Loss, explains that while he is always pleased to have another tool to help patients achieve their weight loss goals, nothing beats a physician-guided program. At The Center For Medical Weight Loss, doctors work with patients to teach them how to lose weight effectively and safely, with customized programs for their specific medical history and metabolic rate.

“While we need additional tools in our weight loss tool kit, people should remember that no medication alone will provide a solution,” says Dr. Kaplan.

The Center for Medical Weight Loss operates 450 centers nationwide. Patients at the centers frequently achieve fast weight loss, dropping on average 11.1 percent of their body weight in just 12 weeks.

To see if there is a center near you, enter your zip code in the box at the right. Special introductory offers are often available for first-time clients.